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KMID : 0605720000060010001
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Journal of the Korean Society of Biological Therapies in Psychiatry
2000 Volume.6 No. 1 p.1 ~ p.11
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Effects of Chlorpromazine, Haloperidol, and Clozapine on the EEG in Rat
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Jeong Sung-Hoon
Park Young-Nam
Lee Maan-Gee
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Abstract
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To evaluate the differential effects of chlopromazine, haloperidol, and clozapine on electroencephalographic(EEG) changes, EEG findings were compared in normal, relaxant, and schizophrenic animal models produced with MK-801 by using power spectral EEG analysis. Under pentobarbital anesthesia, the screw electrodes were implanted on the
skull over the frontal cortex for EEG recording. The EEG was recorded before and after intrapertoneal administration of clozapine(5mg/kg), chlorpromazine(5mg/kg) and haloperidol(1mg/kg) in rats while awaked(the normal group), rats pretreated with a relaxant pancuronium bromide(the relaxant group) and rats pretreated with MK-801(0.2mg/kg, i.p., the MK-801 group). Spectrum analysis of the EEG was used to calculated the powers of each band(delta 1-4Hz; theta 4-8Hz; alpha 8-13Hz; betaL 13-21Hz; betaH 21-30Hz; gamma 30-50Ha; and total 1-50Hz). The EEG activity was
presented as the log value of the relative band power. In the relaxant group, clozapine increased the activity of the delta, theta and alpha bands. Chlorpromazine increased the activity of the betaL band as well as the delta, theta and alpha bands and it decreased the activity of the gamma band. However, haloperidol did not change the activity of all bands significantly. In the MK-801 group, clozapine increased the activity of the delta and gamma bands and chlorpromazine
increased the activity of the delta, bataH and gamma bands significantly. Haloperidol increased the activity of the alpha and betaL bands significantly. To evaluate the differential effects of antipsychotics on EEG between the groups, the ratio of power change after a drug as referenced to pre-drug power in each group was calculated and compared between the groups and was represented by star-like display, In the star-like display, clozapine showed the smallest change and caused a slight shift upwards and to the left, chlorpromazine showed irregular changes, haloperidol showed similar increases along each band
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KEYWORD
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Chlorpromazine, Haloperidol, Clozapine, EEG, MK-801,
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